![]() ![]() It has very little or no activity against influenza B virus isolates. ![]() It does not appear to interfere with the immunogenicity of inactivated influenza A virus vaccine.Īmantadine inhibits the replication of influenza A virus isolates from each of the subtypes, i.e., H1N1, H2N2 and H3N2. In certain cases, amantadine is also known to prevent virus assembly during virus replication. It appears to mainly prevent the release of infectious viral nucleic acid into the host cell by interfering with the function of the transmembrane domain of the viral M2 protein. The mechanism by which amantadine exerts its antiviral activity is not clearly understood. The imprinting ink contains the following: potassium hydroxide, shellac and titanium dioxide. 40, gelatin, sodium lauryl sulfate and titanium dioxide. The capsule shell contains the following: FD&C Blue No. Each capsule also contains the following inactive ingredients: croscarmellose sodium, magnesium stearate, microcrystalline cellulose and pregelatinized starch. It has the following structural formula:Īmantadine hydrochloride, USP is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.Īmantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug.Įach Amantadine Hydrochloride Capsule, USP intended for oral administration contains 100 mg amantadine hydrochloride, USP. ![]() Its molecular weight is 187.71 with a molecular formula Cġ7N.HCl. Amantadine Hydrochloride, USP is designated chemically as 1-adamantanamine hydrochloride. ![]()
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